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integrin αvβ3 antagonist cilengitide  (MedChemExpress)


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    Structured Review

    MedChemExpress integrin αvβ3 antagonist cilengitide
    Integrin αvβ3 Antagonist Cilengitide, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 54 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/%CE%B1v%CE%B23+integrin/Cilengitide/pm41872751-142-14-18
    Average 95 stars, based on 54 article reviews
    integrin αvβ3 antagonist cilengitide - by Bioz Stars, 2026-09
    95/100 stars

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    Related Articles

    Binding Assay:

    Article Title: LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/αvβ3 integrin/FAK-MAPK axis in ICC
    Article Snippet: Lipofectamine 2000 Reagent (Life Technologies, USA) was used for siRNA transfection according to the instructions.Lipofectamine 2000 Reagent (Life Technologies, USA) was used for siRNA transfection according to the instructions.. The inhibitor of the αvβ3 integrin, cyclo (-RGDfK), was purchased from MedChemExpress (MCE; USA) and diluted to 50 μg/μL for stock.. Plasmids of pUC57, pFBLN5 RGD , and pFBLN5 RGE were synthesized by GenScript (Nanjing, China) ( ).Plasmids of pUC57, pFBLN5 RGD , and pFBLN5 RGE were synthesized by GenScript (Nanjing, China) ( ).

    Transfection:

    Article Title: LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/αvβ3 integrin/FAK-MAPK axis in ICC
    Article Snippet: Lipofectamine 2000 Reagent (Life Technologies, USA) was used for siRNA transfection according to the instructions.Lipofectamine 2000 Reagent (Life Technologies, USA) was used for siRNA transfection according to the instructions.. The inhibitor of the αvβ3 integrin, cyclo (-RGDfK), was purchased from MedChemExpress (MCE; USA) and diluted to 50 μg/μL for stock.. Plasmids of pUC57, pFBLN5 RGD , and pFBLN5 RGE were synthesized by GenScript (Nanjing, China) ( ).Plasmids of pUC57, pFBLN5 RGD , and pFBLN5 RGE were synthesized by GenScript (Nanjing, China) ( ).

    Western Blot:

    Article Title: LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/αvβ3 integrin/FAK-MAPK axis in ICC
    Article Snippet: Lipofectamine 2000 Reagent (Life Technologies, USA) was used for siRNA transfection according to the instructions.Lipofectamine 2000 Reagent (Life Technologies, USA) was used for siRNA transfection according to the instructions.. The inhibitor of the αvβ3 integrin, cyclo (-RGDfK), was purchased from MedChemExpress (MCE; USA) and diluted to 50 μg/μL for stock.. Plasmids of pUC57, pFBLN5 RGD , and pFBLN5 RGE were synthesized by GenScript (Nanjing, China) ( ).Plasmids of pUC57, pFBLN5 RGD , and pFBLN5 RGE were synthesized by GenScript (Nanjing, China) ( ).

    Blocking Assay:

    Article Title: LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/αvβ3 integrin/FAK-MAPK axis in ICC
    Article Snippet: Lipofectamine 2000 Reagent (Life Technologies, USA) was used for siRNA transfection according to the instructions.Lipofectamine 2000 Reagent (Life Technologies, USA) was used for siRNA transfection according to the instructions.. The inhibitor of the αvβ3 integrin, cyclo (-RGDfK), was purchased from MedChemExpress (MCE; USA) and diluted to 50 μg/μL for stock.. Plasmids of pUC57, pFBLN5 RGD , and pFBLN5 RGE were synthesized by GenScript (Nanjing, China) ( ).Plasmids of pUC57, pFBLN5 RGD , and pFBLN5 RGE were synthesized by GenScript (Nanjing, China) ( ).

    Phospho-proteomics:

    Article Title: LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/αvβ3 integrin/FAK-MAPK axis in ICC
    Article Snippet: Lipofectamine 2000 Reagent (Life Technologies, USA) was used for siRNA transfection according to the instructions.Lipofectamine 2000 Reagent (Life Technologies, USA) was used for siRNA transfection according to the instructions.. The inhibitor of the αvβ3 integrin, cyclo (-RGDfK), was purchased from MedChemExpress (MCE; USA) and diluted to 50 μg/μL for stock.. Plasmids of pUC57, pFBLN5 RGD , and pFBLN5 RGE were synthesized by GenScript (Nanjing, China) ( ).Plasmids of pUC57, pFBLN5 RGD , and pFBLN5 RGE were synthesized by GenScript (Nanjing, China) ( ).



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    ( a ) Expression of αvβ6 and αvβ3 integrins in pancreatic cancer cell lines. ( a ) Normalized fluorescence measurements showing integrin expression levels in BxPc3, MiaPaca2, and Panc1 cells. BxPc3 cells display significantly higher αvβ6 expression compared with MiaPaca2 and Panc1, whereas αvβ3 expression is detectable at lower levels with a different expression profile across cell lines. Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by post hoc multiple comparison testing; differences were considered statistically significant at *** p < 0.001 (* p < 0.05 where indicated). ( b ) Western blot results showing β6 integrin expression levels normalized to protein concentration (pg β/µg protein) across different PDAC cell lines. BxPc3 expresses high levels of β6 (1411 pg/µg), MiaPaca2 and Panc1 expresses show no detectable levels of this integrin.

    Journal: International Journal of Molecular Sciences

    Article Title: Peptide-Guided Photodynamic Therapy via Integrin αvβ6 in Pancreatic Cancer

    doi: 10.3390/ijms27041838

    Figure Lengend Snippet: ( a ) Expression of αvβ6 and αvβ3 integrins in pancreatic cancer cell lines. ( a ) Normalized fluorescence measurements showing integrin expression levels in BxPc3, MiaPaca2, and Panc1 cells. BxPc3 cells display significantly higher αvβ6 expression compared with MiaPaca2 and Panc1, whereas αvβ3 expression is detectable at lower levels with a different expression profile across cell lines. Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by post hoc multiple comparison testing; differences were considered statistically significant at *** p < 0.001 (* p < 0.05 where indicated). ( b ) Western blot results showing β6 integrin expression levels normalized to protein concentration (pg β/µg protein) across different PDAC cell lines. BxPc3 expresses high levels of β6 (1411 pg/µg), MiaPaca2 and Panc1 expresses show no detectable levels of this integrin.

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    Techniques: Expressing, Fluorescence, Comparison, Western Blot, Protein Concentration